Vitamin D Receptor and Its Influence on Multiple Sclerosis Risk and Severity: From Gene Polymorphisms to Protein Expression

Multiple sclerosis (MS) is a multifactorial neurodegenerative disease. Low levels of vitamin D are risk factor for MS and alterations in the receptor (VDR) might be as well. This study aimed to evaluate whether VDR rs731236 (Taq-I) rs4334089 (HpyCH4V) gene polymorphisms protein expression associated with severity. Vitamin plasma were analyzed group patients. Additional analyses patients different forms (MSSS < 3 MSSS ? 3) performed. The analysis genotypic allelic frequencies revealed that polymorphism significantly presence. Although total, cytosolic nuclear contents do not change between healthy controls severity, decrease parallel an increase MSSS.